| SLOT | PLAYER, TEAM POS | | OPP | STATUS ET | | PRK | PTS | AVG | LAST | | PROJ | PVO | %ST | %OWN | +/- |
| QB | Philip Rivers, SD QB | | | W 32-3 | | 7 | 193 | 21.4 | 21 | | 21 | -4.2 | 71.6 | 100.0 | +0 |
| RB | DeAngelo Williams, Car RB P | | | L 17-24 | | 5 | 191 | 21.2 | 16 | | 21 | -2.5 | 95.7 | 100.0 | +0 |
| RB | Ryan Moats, Hou RB | | | Mon 8:30 | | 52 | 61 | 6.8 | -- | | 10 | -0.5 | 7.2 | 44.8 | -4.1 |
| WR/TE | Dallas Clark, Ind TE | | | W 17-15 | | 1 | 154 | 17.1 | 10 | | 23 | -1.9 | 94.1 | 100.0 | +0 |
| WR/TE | Devery Henderson, NO WR | | | W 38-7 | | 38 | 87 | 9.7 | 11 | | 15 | +5.2 | 28.7 | 55.2 | +4.1 |
| WR/TE | Kevin Walter, Hou WR | | | Mon 8:30 | | 55 | 63 | 7.0 | -- | | 16 | +11.6 | 13.3 | 65.4 | +0.6 |
| D/ST | Bengals D/ST, Cin D/ST | | | L 17-20 | | 8 | 91 | 10.1 | 16 | | 9 | +6.3 | 57.7 | 70.0 | +37 |
| K | Robbie Gould, Chi K | | | L 20-24 | | 16 | 62 | 6.9 | 8 | | 11 | -0.8 | 48.3 | 55.0 | +0 |
| SLOT | PLAYER, TEAM POS | | OPP | STATUS ET | | PRK | PTS | AVG | LAST | | PROJ | PVO | %ST | %OWN | +/- |
| Bench | Matt Ryan, Atl QB | | | L 31-34 | | 16 | 156 | 17.3 | 14 | | 16 | -0.9 | 44.9 | 97.9 | -0.7 |
| Bench | Reggie Bush*, NO RB O | | | W 38-7 | | 24 | 111 | 12.3 | 24 | | 0 | +3.7 | 36.4 | 96.7 | +1.4 |
| Bench | Percy Harvin, Min WR | | | W 35-9 | | 27 | 103 | 11.4 | 8 | | 8 | +4.6 | 34.4 | 96.8 | -0.6 |
| Bench | Jerricho Cotchery, NYJ WR | | | L 14-31 | | 32 | 92 | 10.2 | 18 | | 9 | -1.5 | 15.1 | 72.5 | +1.6 |
| Bench | 49ers D/ST, SF D/ST | | | L 24-30 | | 6 | 94 | 10.4 | 17 | | 6 | -1.1 | 22.5 | 45.7 | +0.2 |
| Bench | Laveranues Coles, Cin WR P | | | L 17-20 | | 52 | 71 | 7.9 | 11 | | 14 | -0.9 | 14.6 | 60.3 | +1.3 |
| Bench | Willis McGahee, Bal RB | | | L 15-17 | | 34 | 86 | 9.6 | 5 | | 4 | -2.2 | 15.3 | 65.1 | -4.1 |
