| SLOT | PLAYER, TEAM POS | | OPP | STATUS ET | | PRK | PTS | AVG | LAST | | PROJ | PVO | %ST | %OWN | +/- |
| QB | Peyton Manning, Ind QB | | | W 17-15 | | 1 | 230 | 25.6 | 32 | | 24 | -1.1 | 91.6 | 100.0 | +0 |
| RB | Pierre Thomas, NO RB | | | W 38-7 | | 19 | 119 | 13.2 | 6 | | 23 | +3.7 | 81.9 | 100.0 | +0 |
| RB | Ricky Williams, Mia RB P | | | W 24-17 | | 15 | 144 | 16.0 | 16 | | 29 | +3 | 68.1 | 98.6 | +0.8 |
| WR/TE | Roddy White, Atl WR P | | | L 31-34 | | 8 | 146 | 16.2 | 16 | | 18 | -3 | 81.3 | 100.0 | +0 |
| WR/TE | Santonio Holmes, Pit WR | | | L 24-27 | | 20 | 113 | 12.6 | 15 | | 19 | +3.2 | 57.3 | 97.9 | +1.3 |
| WR/TE | Vernon Davis, SF TE | | | L 24-30 | | 2 | 134 | 14.9 | 4 | | 16 | +0.8 | 71.5 | 96.7 | +0.4 |
| D/ST | Bears D/ST, Chi D/ST | | | L 20-24 | | 21 | 75 | 8.3 | 8 | | 4 | -3.4 | 38.3 | 62.6 | -4.8 |
| K | Joe Nedney, SF K | | | L 24-30 | | 21 | 55 | 6.1 | 3 | | 8 | -2.1 | 7.6 | 12.1 | -1 |
| SLOT | PLAYER, TEAM POS | | OPP | STATUS ET | | PRK | PTS | AVG | LAST | | PROJ | PVO | %ST | %OWN | +/- |
| Bench | Brandon Jacobs, NYG RB Q | | | W 34-31 | | 24 | 111 | 12.3 | -- | | 19 | +1.1 | 78.1 | 100.0 | +0 |
| Bench | Bernard Berrian, Min WR P | | | W 35-9 | | 48 | 75 | 8.3 | 5 | | 7 | +4.6 | 21.4 | 70.9 | -2.4 |
| Bench | Eli Manning, NYG QB P | | | W 34-31 | | 14 | 160 | 17.8 | -- | | 25 | +2.3 | 29.0 | 97.3 | +0.3 |
| Bench | Jamal Lewis, Cle RB P | | | L 37-38 | | 46 | 66 | 7.3 | 6 | | 18 | +3.4 | 13.0 | 63.3 | +4 |
| Bench | Owen Daniels*, Hou TE IR | | | Mon 8:30 | | 5 | 118 | 13.1 | -- | | 0 | +0.8 | 34.7 | 52.8 | -3.2 |
| Bench | Rob Bironas, Ten K | | | Mon 8:30 | | 12 | 68 | 7.6 | 13 | | 3 | -0.6 | 41.3 | 49.1 | +0.8 |
| Bench | Texans D/ST, Hou D/ST | | | Mon 8:30 | | 23 | 73 | 8.1 | -- | | 2 | -2.1 | 1.6 | 4.8 | -0.3 |
