| RNK | PLAYER, TEAM POS | C/A | YDS | TD | INT | RUSH | YDS | TD | REC | TAR | YDS | TD | PTS |
| 1 | Adrian Peterson , Min RB | 0/0 | 0 | 0 | 0 | 341 | 1701 | 11 | 23 | 42 | 184 | 3 | 272 |
| 2 | Michael Turner , Atl RB | 0/0 | 0 | 0 | 0 | 358 | 1574 | 14 | 4 | 6 | 27 | 0 | 243 |
| 3 | Maurice Jones-Drew , Jac RB | 0/0 | 0 | 0 | 0 | 243 | 1142 | 11 | 65 | 84 | 606 | 2 | 252 |
| 4 | Matt Forte , Chi RB P | 0/0 | 0 | 0 | 0 | 327 | 1210 | 9 | 53 | 76 | 458 | 2 | 232 |
| 5 | Steven Jackson , StL RB | 0/0 | 0 | 0 | 0 | 316 | 1360 | 10 | 43 | 59 | 400 | 1 | 242 |
| 6 | Chris Johnson , Ten RB | 0/0 | 0 | 0 | 0 | 272 | 1335 | 10 | 55 | 71 | 320 | 3 | 243 |
| 7 | LaDainian Tomlinson , SD RB | 0/0 | 0 | 0 | 0 | 294 | 1156 | 11 | 56 | 77 | 478 | 3 | 246 |
| 8 | DeAngelo Williams , Car RB | 0/0 | 0 | 0 | 0 | 267 | 1325 | 11 | 20 | 29 | 117 | 1 | 215 |
| 9 | Larry Fitzgerald , Ari WR | 0/0 | 0 | 0 | 0 | 0 | 0 | 0 | 96 | 154 | 1430 | 13 | 221 |
| 10 | Frank Gore , SF RB | 0/0 | 0 | 0 | 0 | 268 | 1184 | 8 | 51 | 64 | 375 | 1 | 209 |
| 11 | Andre Johnson , Hou WR | 0/0 | 0 | 0 | 0 | 0 | 0 | 0 | 109 | 166 | 1476 | 9 | 201 |
| 12 | Drew Brees , NO QB | 385/597 | 4827 | 30 | 15 | 27 | 44 | 0 | 0 | 0 | 0 | 0 | 287 |
| 13 | Brandon Jacobs , NYG RB | 0/0 | 0 | 0 | 0 | 202 | 1002 | 12 | 4 | 10 | 27 | 0 | 174 |
| 14 | Calvin Johnson , Det WR | 0/0 | 0 | 0 | 0 | 4 | 21 | 0 | 81 | 161 | 1310 | 12 | 205 |
| 15 | Steve Slaton , Hou RB | 0/0 | 0 | 0 | 0 | 288 | 1350 | 8 | 54 | 67 | 428 | 2 | 237 |
| 16 | Tom Brady , NE QB P | 349/540 | 4210 | 33 | 11 | 31 | 46 | 1 | 0 | 0 | 0 | 0 | 288 |
| 17 | Randy Moss , NE WR | 0/0 | 0 | 0 | 0 | 2 | 6 | 0 | 83 | 130 | 1205 | 13 | 198 |
| 18 | Clinton Portis , Was RB | 0/0 | 0 | 0 | 0 | 337 | 1369 | 9 | 21 | 30 | 198 | 0 | 209 |
| 19 | Steve Smith , Car WR | 0/0 | 0 | 0 | 0 | 9 | 64 | 0 | 90 | 149 | 1390 | 9 | 199 |
| 20 | Marion Barber , Dal RB | 0/0 | 0 | 0 | 0 | 223 | 989 | 11 | 44 | 59 | 350 | 2 | 211 |
| 21 | Brian Westbrook , Phi RB Q | 0/0 | 0 | 0 | 0 | 200 | 810 | 7 | 56 | 74 | 453 | 4 | 192 |
| 22 | Peyton Manning , Ind QB | 337/525 | 4153 | 31 | 13 | 20 | 18 | 2 | 0 | 0 | 0 | 0 | 277 |
| 23 | Greg Jennings , GB WR | 0/0 | 0 | 0 | 0 | 0 | 0 | 0 | 79 | 130 | 1303 | 10 | 190 |
| 24 | Reggie Wayne , Ind WR | 0/0 | 0 | 0 | 0 | 0 | 0 | 0 | 88 | 140 | 1319 | 9 | 185 |
| 25 | Kevin Smith , Det RB | 0/0 | 0 | 0 | 0 | 284 | 1146 | 6 | 34 | 50 | 246 | 2 | 186 |
| 26 | Roddy White , Atl WR | 0/0 | 0 | 0 | 0 | 3 | 17 | 0 | 91 | 162 | 1337 | 8 | 182 |
| 27 | Ronnie Brown , Mia RB | 0/0 | 0 | 0 | 0 | 264 | 1135 | 7 | 36 | 53 | 287 | 1 | 189 |
| 28 | Anquan Boldin , Ari WR | 0/0 | 0 | 0 | 0 | 7 | 71 | 0 | 84 | 127 | 1154 | 8 | 170 |
| 29 | Thomas Jones , NYJ RB | 0/0 | 0 | 0 | 0 | 240 | 1094 | 8 | 24 | 34 | 186 | 0 | 175 |
| 30 | Terrell Owens , Buf WR | 0/0 | 0 | 0 | 0 | 9 | 45 | 0 | 83 | 153 | 1174 | 10 | 181 |
| 31 | Marshawn Lynch *, Buf RB O | 0/0 | 0 | 0 | 0 | 219 | 937 | 7 | 38 | 58 | 244 | 1 | 165 |
| 32 | Dwayne Bowe , KC WR | 0/0 | 0 | 0 | 0 | 1 | 1 | 0 | 89 | 161 | 1114 | 9 | 165 |
| 33 | Marques Colston , NO WR P | 0/0 | 0 | 0 | 0 | 0 | 0 | 0 | 58 | 103 | 1002 | 10 | 160 |
| 34 | Kurt Warner , Ari QB | 350/534 | 4150 | 29 | 16 | 16 | 4 | 0 | 0 | 0 | 0 | 0 | 250 |
| 35 | Ryan Grant , GB RB | 0/0 | 0 | 0 | 0 | 301 | 1185 | 6 | 13 | 15 | 94 | 0 | 163 |
| 36 | Brandon Marshall , Den WR P | 0/0 | 0 | 0 | 0 | 1 | 4 | 0 | 88 | 142 | 1109 | 7 | 152 |
| 37 | Pierre Thomas , NO RB P | 0/0 | 0 | 0 | 0 | 217 | 997 | 8 | 21 | 27 | 157 | 0 | 162 |
| 38 | Wes Welker , NE WR | 0/0 | 0 | 0 | 0 | 4 | 27 | 0 | 111 | 149 | 1208 | 5 | 152 |
| 39 | Aaron Rodgers , GB QB | 351/560 | 4008 | 29 | 15 | 61 | 187 | 4 | 0 | 0 | 0 | 0 | 288 |
| 40 | Jonathan Stewart , Car RB P | 0/0 | 0 | 0 | 0 | 196 | 936 | 9 | 9 | 20 | 76 | 0 | 154 |